News

27.11.2018

An artificial multicellular system with spatiotemporal dynamics published in Nature Chemistry

Using water-in-oil droplets, we have created two-dimensional networks of artificial cells separated by lipid bilayer interfaces. Within this "micro-tissue" the cells can communicate via the exchange of small molecule signals. Coupling these signals to cell-free genetic...[more]

22.11.2018

Enhanced Efficiency of an Enzyme Cascade on DNA-Activated Silica Surfaces - published in Langmuir

K. Vogele, J. List, F. C. Simmel, T. Pirzer Langmuir (2018). This article is part of the Nucleic Acids Nanoscience at Interfaces special issue. DOI: 10.1021/acs.langmuir.8b01770 [more]

20.11.2018

Artificial Gel-based Organelles for Spatial Organization of Cell-free Gene Expression Reactions - published in Angewandte Chemie

L. Aufinger, F. C. Simmel Angew. Chem. Int. Ed. 57, published online (2018) DOI: 10.1002/anie.201809374[more]

05.11.2018

A DNA navigator solves mazes on origami - collaboration work with Chunhai Fan and Huajie Liu published in Nature Materials

In a Chinese-German collaboration with Chunhai Fan, Huajie Liu and coworkers, localized DNA strand displacement cascades were realized that allow exploration of paths in tree-like graphs defined on the origami platforms. Read the full story here: J. Chao, J. Wang, F. Wang, X....[more]

29.10.2018

iGEM team wins big at giant jamboree in Boston

This years iGEM team Munich, hosted by the Simmel lab, wins multiple trophies in the overgraduate section at the iGEM giant jamboree: "Best Manufacturing Project", "Best Presentation", "Best Wiki", "Best Software Tool", "Best...[more]

26.10.2018

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography - video article published in JoVE

G. Pardatscher*, M. Schwarz-Schilling*, S. Sagredo, F. C. SimmelJ. Vis. Exp. (140), e58634, (2018)DOI: 10.3791/58634 [more]

21.09.2018

Towards synthetic cells using peptide-based reaction compartments - published in Nature Communications

K. Vogele, T. Frank, L. Gasser, M. A. Goetzfried, M. W. Hackl, S. A. Sieber, F. C. Simmel, and Tobias PirzerNature Communications 9, 3862:1–7 (2018)DOI: 10.1038/s41467-018-06379-8[more]

14.09.2018

Filamentation and restoration of normal growth in Escherichia coli using a combined CRISPRi sgRNA/antisense RNA approach - appeared in PLOS ONE

A. Mückl*, M. Schwarz-Schilling*, K. Fischer, and F. C. SimmelPLOS ONE, 13(9): e0198058 (2018)DOI: 10.1371/journal.pone.0198058[more]

07.05.2018

The Simmel Lab is hosting the 2018 iGEM Munich team

The international Genetically Engineered Machine (iGEM) Competition is the biggest synthetic biology student competition in the world with over 300 teams from 44 countries. Following last year's success, the Simmel lab is again supervising a team of highly motivated students who...[more]

26.03.2018

Optimized Assembly of a Multifunctional RNA-Protein Nanostructure in a Cell-Free Gene Expression System

M. Schwarz-Schilling, A. Dupin, F. Chizzolini, S. Krishnan, S. S. Mansy, and F. C. SimmelNano Letters 18, 2650–2657 (2018)DOI: 10.1021/acs.nanolett.8b00526[more]

19.01.2018

DNA Robot Arm - Perspective Article, Cover image of Science and Animated Video

Perspective article by Björn Högberg: Remote control of nanoscale devices http://science.sciencemag.org/content/359/6373/279 Cover of Science Vol 359, Issue 6373: http://science.sciencemag.org/content/359/6373 Animated video: https://youtu.be/K9fuSVaszyg[more]

15.11.2017

iGem team wins second prize in the world championship in synthetic biology in Boston

After developing their interdisciplinary diagnostics project over the summer in the laboratory of Prof. Dr. Friedrich Simmel, the Munich team (TUM and LMU) was awarded the 1st Runner Up Prize of the "Overgraduate" section. Furthermore, it received special awards in the...[more]

06.12.2016

Condensed DNA maze as cover of Nature Nanotechnology

Cover of Nature Nanotechnology (December 2016). Link Image of the month by 'Wired UK' (02/17) Ten years in images (Nature Nanotechnology anniversary feature). DOI: 10.1038/nnano.2016.190 Image of the month by 'Spektrum der Wissenschaft' (October 2016). Link Images of the...[more]

01.12.2016

Self-Assembled Active Plasmonic Waveguide with a Peptide-Based Thermomechanical Switch

K. Vogele, J. List, G. Pardatscher, N. B. Holland, F. C. Simmel, and T. Pirzer DOI: 10.1021/acsnano.6b06635[more]

29.10.2016

DNA origami rotaxanes chosen as 'Biomedical Picture of the Day'

bpod.mrc.ac.uk/archive/2016/10/29[more]

23.09.2016

Molecular transport through large-diameter DNA nanopores

Swati Krishnan, Daniela Ziegler, Vera Arnaut, Thomas G. Martin, Korbinian Kapsner, Katharina Henneberg, Andreas R. Bausch, Hendrik Dietz & Friedrich C. Simmel DOI:10.1038/ncomms12787[more]

09.09.2016

Friedrich Simmel receives the Rozenberg Tulip Award 2016

“The DNA Computing Scientist 2016” goes to Friedrich Simmel for his contributions in advancing DNA based networks and self-organization of DNA-based systems. isnsce.org/2016/10/05/award-winners-at-dna22/[more]

09.09.2016

Electrotransfection of Polyamine Folded DNA Origami Structures

Aradhana Chopra, Swati Krishnan, and Friedrich C. Simmel DOI: 10.1021/acs.nanolett.6b03586[more]

09.08.2016

DNA dominos on a chip

Normally, individual molecules of genetic material repel each other. However, when space is limited DNA molecules must be packed together more tightly. This case arises in sperm, cell nuclei and the protein shells of viruses. An international team of physicists has now succeeded...[more]