Foto von Tobias Pirzer

Dr. rer. nat. Tobias Pirzer

Technische Universität München

Lehrstuhl für Physik Synthetischer Biosysteme (E14) - (Prof. Simmel)


Am Coulombwall 4a
85748 Garching b. München

Scientific career

2010PhD, Biophysics, TU München
2010 - 2011 Postdoctoral researcher at IMETUM, TU München
2012 - todaySenior Scientist, Simmel Group, TU München


Most important scientific publications

See also:   and


K. Vogele, E. Falgenhauer, S. v. Schönberg, F. C. Simmel, and Tobias Pirzer, Small Antisense DNA-Based Gene Silencing Enables Cell-Free Bacteriophage Manipulation and Genome Replication, ACS Synth. Biol., DOI:10.1021/acssynbio.0c00402 (2021).

T. Frank, K. Vogele, A. Dupin, F. C. Simmel & T. Pirzer, Growth of giant peptide vesicles driven by compartmentalized transcription‐translation activity, Chem. Eur. J. 26, 17356-17360 (2020). doi:10.1002/chem.202003366

M. A. Goetzfried, K. Vogele, A. Mückl, M. Kaiser, N. B. Holland, F. C. Simmel, T. Pirzer, Periodic Operation of a Dynamic DNA Origami Structure Utilizing the Hydrophilic–Hydrophobic Phase-Transition of Stimulus-Sensitive Polypeptides, Small 15, 1903541 (2019).

K. Vogele, T. Pirzer, F. C. Simmel, Genetically encoded membranes for bottom-up biology, ChemSystemsChem 1, e1900016 (2019).

K. Vogele, T. Frank, L. Gasser, M. A. Götzfried, M.W. Hackl, S. A. Sieber, F. C. Simmel, T. Pirzer, In Vesiculo Synthesis of Peptide Membrane Precursors for Autonomous Vesicle Growth, J. Vis. Exp. (148), e59831, doi:10.3791/59831 (2019).

K. Vogele, J. List, F. C. Simmel, T. Pirzer, Enhanced Efficiency of an Enzyme Cascade on DNA-Activated Silica Surfaces, Langmuir 34, 14780–14786 (2018). DOI: 10.1021/acs.langmuir.8b01770

K. Vogele, T. Frank, L. Gasser, M. A. Goetzfried, M. W. Hackl, S. A. Sieber, F. C. Simmel, and Tobias Pirzer, Towards synthetic cells using peptide-based reaction compartments, Nature Communications 9, 3862:1–7 (2018). DOI: 10.1038/s41467-018-06379-8

K. Vogele, J. List, G. Pardatscher, N. B. Holland, F. C. Simmel, and T. Pirzer, A Self-Assembled Active Plasmonic Waveguide with a Peptide-Based Thermo-Mechanical Switch, ACS Nano, ASAP(2016) DOI: 10.1021/acsnano.6b06635

S. Sagredo, T. Pirzer,  A. Aghebat Rafat, M. A. Götzfried, G. Moncalian, F. C. Simmel, F. de la Cruz,  Orthogonal protein assembly on DNA nanostructures using relaxases, Angewandte Chemie Int. Ed. (2016), DOI: 10.1002/anie.201510313

E. Kopperger, T. Pirzer, F. C. Simmel, Diffusive transport of molecular cargo tethered to a DNA origami platform, Nano Letters 15, 2693–2699 (2015). DOI: 10.1021/acs.nanolett.5b00351.

A. Aghebat Rafat, T. Pirzer, M. Scheible, A. Kostina, F. C. Simmel, Surface-Assisted Large-Scale Ordering of DNA Origami Tiles, Angewandte Chemie Int. Ed. 53, 7665-7668 (2014).