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An artificial multicellular system with spatiotemporal dynamics published in Nature Chemistry

27.11.2018


Using water-in-oil droplets, we have created two-dimensional networks of artificial cells separated by lipid bilayer interfaces. Within this "micro-tissue" the cells can communicate via the exchange of small molecule signals. Coupling these signals to cell-free genetic feedback and feedforward circuits results in complex spatiotemporal dynamics in the systems, such as chemical concentration pulses or spatial differentation of initially identical droplets.

Reference:

A. Dupin & F. C. Simmel, Signalling and differentiation in emulsion-based multi-compartmentalized in vitro gene circuits, Nature Chemistry, Advance Online Publication (2018).

https://www.nature.com/articles/s41557-018-0174-9